This EDTA is an artificial amino acid which is to be considered as a foreign mater in the body. It is especially used in case of metal poisoning. Its main application is to bind the metals together and then eradicate from the body. It is easily associated with calcium that is involved in plaque formation in the blood vessels. Chelation therapy can be performed in two ways that can be oral or intravenous chelatian therapy. In intravenous theory, a needle is injected into the veins so as to provide EDTA to the blood stream. In cheration treatment a patient requires a number of sessions of therapy. Preparation of chelatian agents is to be taken orally in the oral chelatian therapy. It performs the same function as of intravenous therapy. But oral therapy is not as much effective as intravenous therapy as it rarely affects plaque that is present in blood vessels. To perform oral therapy, a lot of water has to be taken along the therapy. Chelating agents are present in tablet form in oral therapy. Also chelatin agents are available in form of sprays, powders and suppositories for oral therapy. We can also find Vitamin C and minerals in the chelatian vitamins that are available in the market. Chelatian therapy consists of various advantages. It helps in the reduction of blood clotting, racial activity in blood, calcium absorption and cholesterol level. But the main purpose for using chelatian agents is for metal poisoning. Chelatian agents work as detoxifying agents for the mercury and lead that are present in metals. Atherosclerosis consists of all these benefits. We can also make use of chelatian therapy for the removal of autism as it is able to remove mercury from the brain. Those who are victims of cancer, gastrointestinal, depression can use chelatian therapy. Also chelatian therapy can be used for skin improvements. Even though it is very useful, but it is also not free from side effects. Main side effects of chelatian therapy can consist of excessive calcium removal, bone marrow depression, shock, kidney toxicity and low blood pressure. Though it is surrounded by controversy but still many parts of the chelatian therapy have been approved by the FDA.